2XMM J083026+524133: The most X-ray luminous cluster at redshift 1

In the distant universe X-ray luminous clusters of galaxies are rare objects. Large area surveys are therefore needed to probe the high luminosity end of the cluster population at redshifts z >= 1. We correlated extended X-ray sources from the second XMM-Newton source catalogue (2XMM) with the SDSS in order to identify new clusters of galaxies. Distant cluster candidates in empty SDSS fields were imaged in the R and z bands with the Large Binocular Telescope. We extracted the X-ray spectra of the cluster candidates and fitted thermal plasma models to the data. We determined the redshift 0.99 +-0.03 for 2XMM J083026+524133 from its X-ray spectrum. With a bolometric luminosity of 1.8 x 10^45 erg/sec this is the most X-ray luminous cluster at redshifts z >= 1. We measured a gas temperature of 8.2 +- 0.9 keV and and estimate a cluster mass M(500) = 5.6 x 10^14 M(solar). The optical imaging revealed a rich cluster of galaxies.Comment: New version, as accepted for publication in Astronomy & Astrophysic

Particle Acceleration on Megaparsec Scales in a Merging Galaxy Cluster

Galaxy clusters form through a sequence of mergers of smaller galaxy clusters and groups. Models of diffusive shock acceleration (DSA) suggest that in shocks that occur during cluster mergers, particles are accelerated to relativistic energies, similar to supernova remnants. Together with magnetic fields these particles emit synchrotron radiation and may form so-called radio relics. Here we report the detection of a radio relic for which we find highly aligned magnetic fields, a strong spectral index gradient, and a narrow relic width, giving a measure of the magnetic field in an unexplored site of the universe. Our observations prove that DSA also operates on scales much larger than in supernova remnants and that shocks in galaxy clusters are capable of producing extremely energetic cosmic rays.Comment: Published in Science Express on 23 September 2010, 6 figures, Supporting Online Material included. This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science, volume 330, 15 October 201

Approval of new drugs by the U. S. food and drug administration: Problems with the process and access to unapproved drugs

Today, the vast majority of drugs available for patient use have gone through a rigorous system of human clinical trials supervised by the Food and Drug Administration (FDA), to ensure the drugs are safe and efficacious. There are now citizen advocacy groups that seek use of drugs not yet approved by the FDA, to be administered to terminally ill patients who have exhausted all other available means of therapy. The FDA has programs for terminal patients, under the supervision of their physicians, to use unapproved drugs; however, the advocacy groups seek access to drugs in much earlier phases than is now allowed, raising serious safety concerns for patients. Use of drugs outside of the clinical trials system undermines the integrity of the FDA’s drug development process by slowing enrollment, which in turn slows approval and timely access of safe and efficacious drugs to all of society

X-ray line tomography of AGN-induced motion in clusters of galaxies

The thermal broadening of emission lines of heavy ions is small enough such that Doppler shifts due to bulk motions may be detected with the next generation of X-ray observatories. This opens up the possibility to study gas velocities in the intra-cluster medium. Here we study the effect of bulk motions induced by a central active galactic nucleus (AGN) on the emission lines around the FeXXV complex. We have modelled the evolution of AGN-induced bubbles in a realistic cosmological framework and studied the resulting FeXXV line profiles. We found that in clusters with AGN feedback, motions induced by the inflation of bubbles and their buoyant rise lead to distinct features in the iron emission lines that are detectable with a spectral resolution of about 10 eV. These observations will help to determine the mechanical energy that resides in the bubbles and thereby the kinetic luminosity of the AGN.Comment: to appear in Ap

Diffuse radio emission in the complex merging galaxy cluster Abell 2069

Galaxy clusters with signs for a recent merger show in many cases extended diffuse radio features. This emission originates from relativistic electrons which suffer synchrotron losses due to the intra-cluster magnetic field. The mechanisms of the particle acceleration and the properties of the magnetic field are still poorly understood. We search for diffuse radio emission in galaxy clusters. Here, we study the complex galaxy cluster Abell 2069, for which X-ray observations indicate a recent merger. We investigate the cluster's radio continuum emission by deep Westerbork Synthesis Radio Telescope (WSRT) observations at 346 MHz and a Giant Metrewave Radio Telescope (GMRT) observation at 322 MHz. We find an extended diffuse radio feature roughly coinciding with the main component of the cluster. We classify this emission as a radio halo and estimate its lower limit flux density to 25 +/- 9 mJy. Moreover, we find a second extended diffuse source located at the cluster's companion and estimate its flux density to 15 +/- 2 mJy. We speculate that this is a small halo or a mini-halo. If true, this cluster is the first example of a double-halo in a single galaxy cluster.Comment: 6 pages, 3 figures, accepted for publication in A&